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In the 21st century, people are too busy with their lives and they do not find any time to socialize.You can download the app, start swiping, get matched, and meet up all within a couple hours.Methylazoxymethanol (MAM)-induced microencephalic aged animals with reduced cortical mass and unmodified basal nucleus were used to study the relationship between cells that produce and cells that utilize NGF.Total cortical Ch AT activity of MAM 2, 19 and 27 month old animals was reduced compared to their age-matched controls.To verify whether the reduction of enzyme activity can be ascribed to changes in or ablation of projecting neurons, we carried out immunohistochemical analysis of Ch AT and low affinity NGF receptor (p75NGFR) in the basal nucleus of control and MAM-treated animals.

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Ch AT and p75NGFR immunostaining of basal forebrain cholinergic neurons showed morphological changes in MAM animals, as revealed by cellular atrophy, reduced dendritic arborization and decreased staining intensity.

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